Peer-Reviewed Research on Lumix Superpulsed Laser
Effect of superpulsed laser irradiation on bone formation in human osteoblast-like cell line
Authors: Martinasso G, Mozzati M, Pol R, Canuto RA, Muzio G Journal: Minerva Stomatologica, 2007 PubMed ID: 17287704
Summary: Repeated superpulsed irradiation stimulates cell proliferation and increases expression of proteins essential for bone formation.
Effect of Low-Level Laser Irradiation on Bisphosphonate-Induced Osteonecrosis of the Jaws: Preliminary Results of a Prospective Study
Authors: Scoletta M, Arduino PG, Reggio L et al. Journal: Photomedicine and Laser Surgery, 2009 PubMed ID: 21235406
Summary: Significant improvements observed in pain relief and reduction of lesion size, edema, and presence of pus and fistulas.
Biostimulation Effects of Superpulsed, High-Intensity, Low-Average Power Laser Application on the Timing of Orthodontic Aligner Sequencing of the Invisalign® System
Authors: Marquina N, Stalley F Journal: Journal of Laser Dentistry, 2009
Summary: Laser group had significantly faster aligner sequencing and fewer midcourse corrections.
Effects of Superpulsed Low-Level Laser Therapy on Temporomandibular Joint Pain
Authors: Marini I, Gatto MR, Bonetti GA Journal: The Clinical Journal of Pain, 2010 PubMed ID: 20664343
Summary: Significant pain reduction and significant improved mandibular function with superpulsed laser therapy compared to NSAID and control treatment groups.
The low level laser therapy in the management of neurological burning mouth syndrome. A pilot study
Authors: Romeo U, Del Vecchio A, Capocci M, et al. Journal: Annali di Stomatologia (Roma), 2010 PubMed ID: 22238700
Summary: 68% of treated patients with neurological burning mouth syndrome experienced significant reduction of pain, suggesting potential effectiveness and need for further studies.
Influence of superpulsed laser therapy on healing processes following tooth extraction
Authors: Mozzati M, Martinasso G, Cocero N, et al. Journal: Photomedicine and Laser Surgery, 2011 PubMed ID: 21631375
Summary: Superpulsed laser irradiation prevented increase of multiple inflammatory markers, induced significant collagen increase, reduced pain at site.
Superpulsed laser therapy on healing process after tooth extraction in patients waiting for liver transplantation
Authors: Mozzati M, Martinasso G, Cocero N, et al. Journal: Lasers in Medical Science, 2012 PubMed ID: 21279404
Summary: Superpulsed laser therapy on the alveolar healing process in liver failure patients, stimulated positive epithelial regeneration and reduced pain.
Effects of high-frequency near-infrared diode laser irradiation on the proliferation and migration of mouse calvarial osteoblasts
Authors: Kunimatsu R, Gunji H, Tsuka Y, et al. Journal: Lasers in Medical Science, 2018
Summary: Superpulsed high-frequency laser irradiation enhanced the cellular migration and proliferation of osteoblasts.
High-Frequency Near-Infrared Diode Laser Irradiation Attenuates Il-beta-Induced Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Human Primary Chondrocytes
Authors: Sakata S, Kunimatsu R, Tsuka Y et al. Journal: Journal of Clinical Medicine, 2020 PubMed ID: 32213810
Summary: High-frequency near-infrared diode laser provides high-peak output, low-heat accumulation and efficient biostimulation that significantly attenuated the upregulated inflammatory proteins in chondrocytes.
Effects of high-frequency near infrared laser irradiation on experimental tooth movement-induced pain in rats
Authors: Nakatani A, Kunimatsu R, Tsuka Y, et al. Journal: Lasers in Medical Science, 2022 PubMed ID: 35695995
Summary: High-frequency near-infrared diode laser irradiation produced significant analgesic effects during experimental tooth movement in rats, suggesting application for pain reduction during orthodontic tooth movement.
Investigating the Effect of High Power Laser in Improving the Clinical Symptoms of Patients with Rotator Cuff Tendinopathy: A Randomized Clinical Trial
Authors: Maghroori R, Haghighat S, Berimanloo HM Journal: Middle East Journal of Rehabilitation and Health Studies, 2024
Summary: A randomized clinical trial; high-power laser therapy produced significantly greater reduction of VAS scores, and significantly improved DASH scores in patients with rotator cuff tendinopathy, compared to NSAID treatment; both treatments in combination with physiotherapy.
Potential of combined red and near-infrared photobiomodulation to mitigate pro-osteoclastic and inflammatory gene expression in human mandibular osteogenic cells
Authors: Palmisano B, Del Vecchio A, Passaretti A, et al. Journal: Lasers in Medical Science, 2024 PubMed ID: 39349883
Summary: Examined in vitro cellular mechanisms. Treatment significantly reduces expression of inflammatory genes IL-6, IL-1β, and the osteoclast activator RANKL.
Laser-related Research Activities – Dr Nelson Marquina
He is the author of the chapter Energy Medicine: Focus on Lasers in the third edition (2017) of the book, The Scientific Basis of Integrative Health. In clinical and lay language, the chapter leverages the benefits and integration of therapeutic lasers into medicine and healthcare. Dr. Marquina also contributed a chapter in the 2015 book Pain Relief and Healing with Lasers: Dental Protocols of Laser Treatments released in Japan.
He is an author/co-author of journal and research publications, most recently in laser-related works:
- “Biostimulation Effects of Superpulsed, High-Intensity, Low-Average Power Laser Application on the Timing of Orthodontic Aligner Sequencing of the Invisalign System” in Journal of Laser Dentistry
- “Effect of Laser Acupoint Treatment on Blood Pressure and Body Weight – a Pilot Study” in Journal of Chiropractic Medicine
- “Sagittal Plane Lumbar Spine Geometry Correlated to MRI Disc Pathology in Acute and Chronic Lower Back Pain” in Journal of Manipulative and Physiological Therapeutics
- “Laser Therapy Applications for Osteoarthritis and Chronic Joint Pain – A Randomized Placebo-controlled Clinical Trial” in Photon Lasers Medicine
- “Tissue Regeneration Effect of High Intensity Diode Cold Lasers and the Clinical Applications in Periodontal Therapy” at 18th International Society for Laser Surgery and Medicine Congress – Laser Tokyo 2009
- “Low Level Laser Therapy on Knee Osteoarthritis” at Association of Chiropractic Colleges Annual Research Directors Conference